Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent strom...

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Detalles Bibliográficos
Autores principales: Dean, J P, Nelson, P S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361445/
https://www.ncbi.nlm.nih.gov/pubmed/18182995
http://dx.doi.org/10.1038/sj.bjc.6604087
Descripción
Sumario:Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.

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