Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent strom...

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Detalles Bibliográficos
Autores principales: Dean, J P, Nelson, P S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361445/
https://www.ncbi.nlm.nih.gov/pubmed/18182995
http://dx.doi.org/10.1038/sj.bjc.6604087
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author Dean, J P
Nelson, P S
author_facet Dean, J P
Nelson, P S
author_sort Dean, J P
collection PubMed
description Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.
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spelling pubmed-23614452009-09-10 Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis Dean, J P Nelson, P S Br J Cancer Minireview Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets. Nature Publishing Group 2008-01-29 2008-01-08 /pmc/articles/PMC2361445/ /pubmed/18182995 http://dx.doi.org/10.1038/sj.bjc.6604087 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Dean, J P
Nelson, P S
Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
title Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
title_full Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
title_fullStr Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
title_full_unstemmed Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
title_short Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
title_sort profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361445/
https://www.ncbi.nlm.nih.gov/pubmed/18182995
http://dx.doi.org/10.1038/sj.bjc.6604087
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