The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines

Clinical usefulness of doxorubicin (DOX) is limited by the occurrence of multidrug resistance (MDR) associated with the presence of membrane transporters (e.g. P-glycoprotein, MRP1) responsible for the active efflux of drugs out of resistant cells. Doxorubicin is a well-known bioreductive antitumour...

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Detalles Bibliográficos
Autores principales: Kostrzewa-Nowak, D, Paine, M J I, Wolf, C R, Tarasiuk, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361480/
https://www.ncbi.nlm.nih.gov/pubmed/15942634
http://dx.doi.org/10.1038/sj.bjc.6602639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361480/
https://www.ncbi.nlm.nih.gov/pubmed/15942634
http://dx.doi.org/10.1038/sj.bjc.6602639

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