Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells

Neuropilin-1 (NRP-1) is a novel co-receptor for vascular endothelial growth factor (VEGF). Neuropilin-1 is expressed in pancreatic cancer, but not in nonmalignant pancreatic tissue. We hypothesised that NRP-1 expression by pancreatic cancer cells contributes to the malignant phenotype. To determine...

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Detalles Bibliográficos
Autores principales: Wey, J S, Gray, M J, Fan, F, Belcheva, A, McCarty, M F, Stoeltzing, O, Somcio, R, Liu, W, Evans, D B, Klagsbrun, M, Gallick, G E, Ellis, L M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361553/
https://www.ncbi.nlm.nih.gov/pubmed/15956974
http://dx.doi.org/10.1038/sj.bjc.6602663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361553/
https://www.ncbi.nlm.nih.gov/pubmed/15956974
http://dx.doi.org/10.1038/sj.bjc.6602663

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