Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

Easily accessible normal tissues expressing the same molecular site(s) of drug action as malignant tissue offer an enhanced potential for early proof of anticancer drug mechanism and estimation of the biologically effective dose. Studies were undertaken in healthy male volunteers to assess the toler...

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Detalles Bibliográficos
Autores principales: Camidge, D R, Pemberton, M N, Growcott, J W, Johnstone, D, Laud, P J, Foster, J R, Randall, K J, Hughes, A M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361555/
https://www.ncbi.nlm.nih.gov/pubmed/15999099
http://dx.doi.org/10.1038/sj.bjc.6602686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361555/
https://www.ncbi.nlm.nih.gov/pubmed/15999099
http://dx.doi.org/10.1038/sj.bjc.6602686

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