High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma

Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal origin, although the mechanisms involved in the decision of a cell to activate either telomerase or ALT...

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Detalles Bibliográficos
Autores principales: Cairney, C J, Hoare, S F, Daidone, M-G, Zaffaroni, N, Keith, W N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361713/
https://www.ncbi.nlm.nih.gov/pubmed/18414473
http://dx.doi.org/10.1038/sj.bjc.6604328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361713/
https://www.ncbi.nlm.nih.gov/pubmed/18414473
http://dx.doi.org/10.1038/sj.bjc.6604328

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