Adjuvant sequential methotrexate → 5-fluorouracil vs 5-fluorouracil plus leucovorin in radically resected stage III and high-risk stage II colon cancer

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The aim of the study was to determine whether modulation of 5-fluorouracil (FU) by methotrexate (MTX) improves survival compared to FU+6-s-leucovorin (LV) following potentially curative resection of stage II and III colon cancer. Within 8 weeks from surgery, 1945 patients with stage III (44%) or hig...

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Detalles Bibliográficos
Autores principales: Sobrero, A, Frassineti, G, Falcone, A, Dogliotti, L, Rosso, R, Costanzo, F D, Bruzzi, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361725/
https://www.ncbi.nlm.nih.gov/pubmed/15611795
http://dx.doi.org/10.1038/sj.bjc.6602276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361725/
https://www.ncbi.nlm.nih.gov/pubmed/15611795
http://dx.doi.org/10.1038/sj.bjc.6602276

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