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Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening

Sweden was the first country to establish a nationwide breast cancer screening service. We used the Swedish Family-Cancer Database to evaluate the risk of invasive carcinoma after in situ carcinoma of the breast. Risk estimates for contralateral and ipsilateral invasive malignancies following age an...

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Autores principales: Rawal, R, Bermejo, J Lorenzo, Hemminki, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361754/
https://www.ncbi.nlm.nih.gov/pubmed/15570309
http://dx.doi.org/10.1038/sj.bjc.6602250
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author Rawal, R
Bermejo, J Lorenzo
Hemminki, K
author_facet Rawal, R
Bermejo, J Lorenzo
Hemminki, K
author_sort Rawal, R
collection PubMed
description Sweden was the first country to establish a nationwide breast cancer screening service. We used the Swedish Family-Cancer Database to evaluate the risk of invasive carcinoma after in situ carcinoma of the breast. Risk estimates for contralateral and ipsilateral invasive malignancies following age and histology specific in situ breast carcinomas were calculated using Poisson's regression analysis. The agreement between concordant and discordant morphologies of invasive and in situ breast cancer was measured using the kappa statistic. Women with in situ breast cancer showed a relative risk of 2.03 for contralateral and 3.94 for ipsilateral invasive breast cancer. The risk was higher for in situ carcinomas diagnosed before the age of 50 years and after lobular in situ breast cancers. A comparison of the risks during the past decades suggested that the risk of ipsilateral breast cancer has increased in Sweden but that of contralateral breast cancer has remained unchanged. In situ and the subsequent invasive breast cancers did not seem to share their morphologies.
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spelling pubmed-23617542009-09-10 Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening Rawal, R Bermejo, J Lorenzo Hemminki, K Br J Cancer Epidemiology Sweden was the first country to establish a nationwide breast cancer screening service. We used the Swedish Family-Cancer Database to evaluate the risk of invasive carcinoma after in situ carcinoma of the breast. Risk estimates for contralateral and ipsilateral invasive malignancies following age and histology specific in situ breast carcinomas were calculated using Poisson's regression analysis. The agreement between concordant and discordant morphologies of invasive and in situ breast cancer was measured using the kappa statistic. Women with in situ breast cancer showed a relative risk of 2.03 for contralateral and 3.94 for ipsilateral invasive breast cancer. The risk was higher for in situ carcinomas diagnosed before the age of 50 years and after lobular in situ breast cancers. A comparison of the risks during the past decades suggested that the risk of ipsilateral breast cancer has increased in Sweden but that of contralateral breast cancer has remained unchanged. In situ and the subsequent invasive breast cancers did not seem to share their morphologies. Nature Publishing Group 2005-01-17 2004-11-30 /pmc/articles/PMC2361754/ /pubmed/15570309 http://dx.doi.org/10.1038/sj.bjc.6602250 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Rawal, R
Bermejo, J Lorenzo
Hemminki, K
Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
title Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
title_full Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
title_fullStr Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
title_full_unstemmed Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
title_short Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
title_sort risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361754/
https://www.ncbi.nlm.nih.gov/pubmed/15570309
http://dx.doi.org/10.1038/sj.bjc.6602250
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