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The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells

The phosphatidylinositol 3′ kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and survival, is mutated or activated in a wide variety of cancers. Akt appears to be a key central node in this pathway and thus is a...

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Detalles Bibliográficos
Autores principales: Mandal, M, Kim, S, Younes, M N, Jasser, S A, El-Naggar, A K, Mills, G B, Myers, J N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361761/
https://www.ncbi.nlm.nih.gov/pubmed/15870708
http://dx.doi.org/10.1038/sj.bjc.6602595