Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines

Imatinib mesylate (IM) is a tyrosine kinase inhibitor, which inhibits phosphorylation of downstream proteins involved in BCR-ABL signal transduction. It has proved beneficial in treating patients with chronic myeloid leukaemia (CML). In addition, IM demonstrates activity against malignant cells expr...

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Detalles Bibliográficos
Autores principales: Uziel, O, Fenig, E, Nordenberg, J, Beery, E, Reshef, H, Sandbank, J, Birenbaum, M, Bakhanashvili, M, Yerushalmi, R, Luria, D, Lahav, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361771/
https://www.ncbi.nlm.nih.gov/pubmed/15870711
http://dx.doi.org/10.1038/sj.bjc.6602592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361771/
https://www.ncbi.nlm.nih.gov/pubmed/15870711
http://dx.doi.org/10.1038/sj.bjc.6602592

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