Role of insulin-like growth factor 1 receptor signalling in cancer

The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal ce...

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Autores principales: Larsson, O, Girnita, A, Girnita, L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361813/
https://www.ncbi.nlm.nih.gov/pubmed/15956962
http://dx.doi.org/10.1038/sj.bjc.6602627
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author Larsson, O
Girnita, A
Girnita, L
author_facet Larsson, O
Girnita, A
Girnita, L
author_sort Larsson, O
collection PubMed
description The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal cell growth. This is in part due to the interactions with oncogenes. Recent findings suggest a close interplay with the p53/MDM2 pathway. Disturbances in components in the p53/MDM2/IGF-1R network may cause IGF-1R upregulation and growth advantage for the cancer cell. Targeting of IGF-1R is more and more seen as a promising option for future cancer therapy. Single chain antibodies and small molecules with selective effects on IGF-1R dependent malignant growth are of particular interest. Forthcoming clinical trials are welcome and will indeed be the only way to evaluate the impact of IGF-1R targeting in human cancer.
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spelling pubmed-23618132009-09-10 Role of insulin-like growth factor 1 receptor signalling in cancer Larsson, O Girnita, A Girnita, L Br J Cancer Minireview The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal cell growth. This is in part due to the interactions with oncogenes. Recent findings suggest a close interplay with the p53/MDM2 pathway. Disturbances in components in the p53/MDM2/IGF-1R network may cause IGF-1R upregulation and growth advantage for the cancer cell. Targeting of IGF-1R is more and more seen as a promising option for future cancer therapy. Single chain antibodies and small molecules with selective effects on IGF-1R dependent malignant growth are of particular interest. Forthcoming clinical trials are welcome and will indeed be the only way to evaluate the impact of IGF-1R targeting in human cancer. Nature Publishing Group 2005-06-20 2005-05-24 /pmc/articles/PMC2361813/ /pubmed/15956962 http://dx.doi.org/10.1038/sj.bjc.6602627 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Larsson, O
Girnita, A
Girnita, L
Role of insulin-like growth factor 1 receptor signalling in cancer
title Role of insulin-like growth factor 1 receptor signalling in cancer
title_full Role of insulin-like growth factor 1 receptor signalling in cancer
title_fullStr Role of insulin-like growth factor 1 receptor signalling in cancer
title_full_unstemmed Role of insulin-like growth factor 1 receptor signalling in cancer
title_short Role of insulin-like growth factor 1 receptor signalling in cancer
title_sort role of insulin-like growth factor 1 receptor signalling in cancer
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361813/
https://www.ncbi.nlm.nih.gov/pubmed/15956962
http://dx.doi.org/10.1038/sj.bjc.6602627
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