Role of survivin and its splice variants in tumorigenesis

Survivin, a unique member of the inhibitor of apoptosis (IAP) protein family, is highly expressed in cancer but is undetectable in nonproliferating normal adult tissues, suggesting a potential role in tumorigenesis. Differential splicing of survivin pre-mRNA results in three new survivin variants, s...

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Detalles Bibliográficos
Autor principal: Li, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361850/
https://www.ncbi.nlm.nih.gov/pubmed/15611788
http://dx.doi.org/10.1038/sj.bjc.6602340
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author Li, F
author_facet Li, F
author_sort Li, F
collection PubMed
description Survivin, a unique member of the inhibitor of apoptosis (IAP) protein family, is highly expressed in cancer but is undetectable in nonproliferating normal adult tissues, suggesting a potential role in tumorigenesis. Differential splicing of survivin pre-mRNA results in three new survivin variants, survivin-ΔEx3, survivin-2B, and survivin-3B. Loss of survivin-2B expression was found in the later stage of cancer development, while survivin and survivin-ΔEx3 are not, suggesting a differential role of them in tumour development. In this minireview, the author intends to summarise and discuss the current data relevant to the role of survivin and its splicing variants in tumorigenesis, which may facilitate further investigation in this interesting area.
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spelling pubmed-23618502009-09-10 Role of survivin and its splice variants in tumorigenesis Li, F Br J Cancer Minireview Survivin, a unique member of the inhibitor of apoptosis (IAP) protein family, is highly expressed in cancer but is undetectable in nonproliferating normal adult tissues, suggesting a potential role in tumorigenesis. Differential splicing of survivin pre-mRNA results in three new survivin variants, survivin-ΔEx3, survivin-2B, and survivin-3B. Loss of survivin-2B expression was found in the later stage of cancer development, while survivin and survivin-ΔEx3 are not, suggesting a differential role of them in tumour development. In this minireview, the author intends to summarise and discuss the current data relevant to the role of survivin and its splicing variants in tumorigenesis, which may facilitate further investigation in this interesting area. Nature Publishing Group 2005-01-31 2004-12-21 /pmc/articles/PMC2361850/ /pubmed/15611788 http://dx.doi.org/10.1038/sj.bjc.6602340 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Li, F
Role of survivin and its splice variants in tumorigenesis
title Role of survivin and its splice variants in tumorigenesis
title_full Role of survivin and its splice variants in tumorigenesis
title_fullStr Role of survivin and its splice variants in tumorigenesis
title_full_unstemmed Role of survivin and its splice variants in tumorigenesis
title_short Role of survivin and its splice variants in tumorigenesis
title_sort role of survivin and its splice variants in tumorigenesis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361850/
https://www.ncbi.nlm.nih.gov/pubmed/15611788
http://dx.doi.org/10.1038/sj.bjc.6602340
work_keys_str_mv AT lif roleofsurvivinanditssplicevariantsintumorigenesis

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