Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: effects on cell survival, cell cycle and pharmacogenetic profile

The pyrimidine analogue gemcitabine is an established effective agent in the treatment of non-small-cell lung cancer (NSCLC). The present study investigates whether gemcitabine would be synergistic with the topoisomerase I inhibitor topotecan against the NSCLC A549 and Calu-6 cells. Cells were treat...

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Detalles Bibliográficos
Autores principales: Giovannetti, E, Mey, V, Danesi, R, Basolo, F, Barachini, S, Deri, M, Del Tacca, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361886/
https://www.ncbi.nlm.nih.gov/pubmed/15700043
http://dx.doi.org/10.1038/sj.bjc.6602382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361886/
https://www.ncbi.nlm.nih.gov/pubmed/15700043
http://dx.doi.org/10.1038/sj.bjc.6602382

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