Altered expression of topoisomerase IIα contributes to cross-resistant to etoposide K562/MX2 cell line by aberrant methylation

KRN 8602 (MX2) is a novel morpholino anthracycline derivative having the chemical structure 3′-deamino-3′-morpholino-13-deoxo-10-hydroxycarminomycin hydrochloride. To investigate the mechanisms of resistance to MX2, we established an MX2-resistant phenotype (K562/MX2) of the human myelogeneous leuka...

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Detalles Bibliográficos
Autores principales: Asano, T, Nakamura, K, Fujii, H, Horichi, N, Ohmori, T, Hasegawa, K, Isoe, T, Adachi, M, Otake, N, Fukunaga, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362017/
https://www.ncbi.nlm.nih.gov/pubmed/15798770
http://dx.doi.org/10.1038/sj.bjc.6602498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362017/
https://www.ncbi.nlm.nih.gov/pubmed/15798770
http://dx.doi.org/10.1038/sj.bjc.6602498

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