A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels

Dihydropyridines (DHPs) are L-type calcium channel (Ca(v)1) blockers prescribed to treat several diseases including hypertension. Ca(v)1 channels normally exist in three states: a resting closed state, an open state that is triggered by membrane depolarization, followed by a non-conducting inactivat...

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Detalles Bibliográficos
Autores principales: Kwok, Trevor C. Y., Hui, Kwokyin, Kostelecki, Wojciech, Ricker, Nicole, Selman, Guillermo, Feng, Zhong-Ping, Roy, Peter John
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362100/
https://www.ncbi.nlm.nih.gov/pubmed/18464914
http://dx.doi.org/10.1371/journal.pgen.1000067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362100/
https://www.ncbi.nlm.nih.gov/pubmed/18464914
http://dx.doi.org/10.1371/journal.pgen.1000067

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