Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

To gain more insight into the pharmacological role of endogenous P-glycoprotein in the metabolism of the widely used substrate drug doxorubicin, we have studied the plasma pharmacokinetics, tissue distribution and excretion of this compound in mdr1a(–/– and wild-type mice. Doxorubicin was administer...

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Detalles Bibliográficos
Autores principales: Asperen, J van, Tellingen, O van, Tijssen, F, Schinkel, A H, Beijnen, J H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362153/
https://www.ncbi.nlm.nih.gov/pubmed/10408701
http://dx.doi.org/10.1038/sj.bjc.6690019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362153/
https://www.ncbi.nlm.nih.gov/pubmed/10408701
http://dx.doi.org/10.1038/sj.bjc.6690019

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