Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia

Mutations of the p53 tumour suppressor gene are infrequent at presentation of both acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL), being found in between 5–10% of AML and 2–3% of ALL. Here we have studied the frequency of detection of p53 mutations at relapse of both AML...

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Detalles Bibliográficos
Autores principales: Zhu, Y-M, Foroni, L, McQuaker, I G, Papaioannou, M, Haynes, A, Russell, H H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362216/
https://www.ncbi.nlm.nih.gov/pubmed/10098750
http://dx.doi.org/10.1038/sj.bjc.6690183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362216/
https://www.ncbi.nlm.nih.gov/pubmed/10098750
http://dx.doi.org/10.1038/sj.bjc.6690183

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