Restoration of p16(INK4A) protein induces myogenic differentiation in RD rhabdomyosarcoma cells

p16(INK4A) (p16) tumour suppressor induces growth arrest by inhibiting function of cyclin-dependent kinase (CDK)4 and CDK6. Homozygous p16 gene deletion is frequent in primary rhabdomyosarcoma (RMS) cells as well as derived cell lines. To confirm the significance of p16 gene deletion in tumour biolo...

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Detalles Bibliográficos
Autores principales: Urashima, M, Teoh, G, Akiyama, M, Yuza, Y, Anderson, K C, Maekawa, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362237/
https://www.ncbi.nlm.nih.gov/pubmed/10098732
http://dx.doi.org/10.1038/sj.bjc.6690165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362237/
https://www.ncbi.nlm.nih.gov/pubmed/10098732
http://dx.doi.org/10.1038/sj.bjc.6690165

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