Evidence for two candidate tumour suppressor loci on chromosome 9q in transitional cell carcinoma (TCC) of the bladder but no homozygous deletions in bladder tumour cell lines

The most frequent genetic alterations in transitional cell carcinoma (TCC) of the bladder involve loss of heterozygosity (LOH) on chromosome 9p and 9q. The LOH on chromosome 9p most likely targets the CDKN2 locus, which is inactivated in about 50% of TCCs. Candidate genes that are the target for LOH...

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Detalles Bibliográficos
Autores principales: Tilborg, A A G van, Groenfeld, L E, Kwast, T H van der, Zwarthoff, E C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362340/
https://www.ncbi.nlm.nih.gov/pubmed/10408858
http://dx.doi.org/10.1038/sj.bjc.6690383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362340/
https://www.ncbi.nlm.nih.gov/pubmed/10408858
http://dx.doi.org/10.1038/sj.bjc.6690383

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