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Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

A series of hydroxamates, which are not metalloprotease inhibitors, have been found to be selectively toxic to a range of transformed and human tumour cells without killing normal cells (fibroblasts, melanocytes) at the same concentrations. Within 24 h of treatment, drug action is characterized by m...

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Detalles Bibliográficos
Autores principales: Qiu, L, Kelso, M J, Hansen, C, West, M L, Fairlie, D P, Parsons, P G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362353/
https://www.ncbi.nlm.nih.gov/pubmed/10376979
http://dx.doi.org/10.1038/sj.bjc.6690493