An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4(scFv)-ETÁ) is a potent immunotoxin against a Hodgkin-derived cell line

The human CD30 receptor is highly overexpressed on the surface of Hodgkin Reed-Sternberg cells and has been shown to be an excellent target for selective immunotherapy using monoclonal antibody-based agents such as immunotoxins. To construct a new recombinant immunotoxin for possible clinical use in...

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Detalles Bibliográficos
Autores principales: Klimka, A, Barth, S, Matthey, B, Roovers, R C, Lemke, H, Hansen, H, Arends, J-W, Diehl, V, Hoogenboom, H R, Engert, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362362/
https://www.ncbi.nlm.nih.gov/pubmed/10376974
http://dx.doi.org/10.1038/sj.bjc.6690488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362362/
https://www.ncbi.nlm.nih.gov/pubmed/10376974
http://dx.doi.org/10.1038/sj.bjc.6690488

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