G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder

The G1 cell cycle checkpoint regulates entry into S phase for normal cells. Components of the G1 checkpoint, including retinoblastoma (Rb) protein, cyclin D1 and p16(INK4a), are commonly altered in human malignancies, abrogating cell cycle control. Using immunohistochemistry, we examined 79 invasive...

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Detalles Bibliográficos
Autores principales: Niehans, G A, Kratzke, R A, Froberg, M K, Aeppli, D M, Nguyen, P L, Geradts, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362363/
https://www.ncbi.nlm.nih.gov/pubmed/10376969
http://dx.doi.org/10.1038/sj.bjc.6990483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362363/
https://www.ncbi.nlm.nih.gov/pubmed/10376969
http://dx.doi.org/10.1038/sj.bjc.6990483

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