Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase

DT-diaphorase is a two-electron reducing enzyme that activates the bioreductive anti-tumour agent, mitomycin C (MMC). Cell lines having elevated levels of DT-diaphorase are generally more sensitive to MMC. We have shown that DT-diaphorase can be induced in human tumour cells by a number of compounds...

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Detalles Bibliográficos
Autores principales: Wang, X, Doherty, G P, Leith, M K, Curphey, T J, Begleiter, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362377/
https://www.ncbi.nlm.nih.gov/pubmed/10376975
http://dx.doi.org/10.1038/sj.bjc.6690489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362377/
https://www.ncbi.nlm.nih.gov/pubmed/10376975
http://dx.doi.org/10.1038/sj.bjc.6690489

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