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Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase
DT-diaphorase is a two-electron reducing enzyme that activates the bioreductive anti-tumour agent, mitomycin C (MMC). Cell lines having elevated levels of DT-diaphorase are generally more sensitive to MMC. We have shown that DT-diaphorase can be induced in human tumour cells by a number of compounds...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362377/ https://www.ncbi.nlm.nih.gov/pubmed/10376975 http://dx.doi.org/10.1038/sj.bjc.6690489 |