Induction of MDR1 gene expression by anthracycline analogues in a human drug resistant leukaemia cell line

The effects of 4-demethoxydaunorubicin (idarubicin, IDA) and MX2, a new morpholino-anthracycline, on up-regulation of the MDR1 gene in the low-level multidrug resistant (MDR) cell line CEM/A7R were compared at similar concentrations (IC(10), IC(50)and IC(90)) over a short time exposure (4 and 24 h)....

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Detalles Bibliográficos
Autores principales: Hu, X F, Slater, A, Rischin, D, Kantharidis, P, Parkin, J D, Zalcberg, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362657/
https://www.ncbi.nlm.nih.gov/pubmed/10070877
http://dx.doi.org/10.1038/sj.bjc.6990133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362657/
https://www.ncbi.nlm.nih.gov/pubmed/10070877
http://dx.doi.org/10.1038/sj.bjc.6990133

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