Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

Reduced expression of BRCA1 has been implicated in sporadic breast cancer, although the mechanisms underlying this phenomenon remain unclear. To determine whether regulatory mutations could account for the reduced expression, we screened the promoter region by sequencing in 20 patients with sporadic...

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Detalles Bibliográficos
Autores principales: Catteau, A, Xu, C-F, Brown, M A, Hodgson, S, Greenman, J, Mathew, C G, Dunning, A M, Solomon, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362680/
https://www.ncbi.nlm.nih.gov/pubmed/10070866
http://dx.doi.org/10.1038/sj.bjc.6690122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362680/
https://www.ncbi.nlm.nih.gov/pubmed/10070866
http://dx.doi.org/10.1038/sj.bjc.6690122

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