The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells

The accumulation and toxicity of the weak base doxorubicin has been investigated as a function of extracellular pH, intracellular pH and the cellular pH gradient in cells previously cultured under normal (pH 7.4) and low-pH (6.8) conditions. Low-pH-adapted cells exhibit transmembrane pH gradients wh...

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Detalles Bibliográficos
Autores principales: Gerweck, L E, Kozin, S V, Stocks, S J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362684/
https://www.ncbi.nlm.nih.gov/pubmed/10070878
http://dx.doi.org/10.1038/sj.bjc.6690134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362684/
https://www.ncbi.nlm.nih.gov/pubmed/10070878
http://dx.doi.org/10.1038/sj.bjc.6690134

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