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The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells
The accumulation and toxicity of the weak base doxorubicin has been investigated as a function of extracellular pH, intracellular pH and the cellular pH gradient in cells previously cultured under normal (pH 7.4) and low-pH (6.8) conditions. Low-pH-adapted cells exhibit transmembrane pH gradients wh...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362684/ https://www.ncbi.nlm.nih.gov/pubmed/10070878 http://dx.doi.org/10.1038/sj.bjc.6690134 |