RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropionic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin–oxygen (Hb–O(2)) affinity, improved tumour oxygenation, and enhan...

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Detalles Bibliográficos
Autores principales: Khandelwal, S R, Kavanagh, B D, Lin, P-S, Truong, Q T, Lu, J, Abraham*, D J, Schmidt-Ullrich, R K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362693/
https://www.ncbi.nlm.nih.gov/pubmed/10070874
http://dx.doi.org/10.1038/sj.bjc.6690130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362693/
https://www.ncbi.nlm.nih.gov/pubmed/10070874
http://dx.doi.org/10.1038/sj.bjc.6690130

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