A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

Three lipophilic quinazoline-based aminomethyl pyridine compounds, which differ only in the position of the nitrogen in their pyridine ring, are described. CB300179 (2-pyridine), CB300189 (4-pyridine) and CB30865 (3-pyridine) all inhibited isolated mammalian TS with IC(50) values of 508, 250 and 156...

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Detalles Bibliográficos
Autores principales: Skelton, L A, Ormerod, M G, Titley, J, Kimbell, R, Brunton, L A, Jackman, A L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362793/
https://www.ncbi.nlm.nih.gov/pubmed/10206279
http://dx.doi.org/10.1038/sj.bjc.6690270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362793/
https://www.ncbi.nlm.nih.gov/pubmed/10206279
http://dx.doi.org/10.1038/sj.bjc.6690270

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