Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor

Hereditary non-polyposis colorectal cancer (HNPCC) is linked to an inherited defect in the DNA mismatch repair system. DNA from HNPCC tumours shows microsatellite instability (MSI). It has been reported that HNPCC patients have a better prognosis than patients with sporadic colorectal cancer. We exa...

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Detalles Bibliográficos
Autores principales: Salahshor, S, Kressner, U, Fischer, H, Lindmark, G, Glimelius, B, Påhlman, L, Lindblom, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362857/
https://www.ncbi.nlm.nih.gov/pubmed/10496341
http://dx.doi.org/10.1038/sj.bjc.6690676
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author Salahshor, S
Kressner, U
Fischer, H
Lindmark, G
Glimelius, B
Påhlman, L
Lindblom, A
author_facet Salahshor, S
Kressner, U
Fischer, H
Lindmark, G
Glimelius, B
Påhlman, L
Lindblom, A
author_sort Salahshor, S
collection PubMed
description Hereditary non-polyposis colorectal cancer (HNPCC) is linked to an inherited defect in the DNA mismatch repair system. DNA from HNPCC tumours shows microsatellite instability (MSI). It has been reported that HNPCC patients have a better prognosis than patients with sporadic colorectal cancer. We examined whether the presence of MSI in a series of unselected colorectal tumours carries prognostic information. In a series of 181 unselected colorectal tumours, 22 tumours (12%) showed MSI. Survival analysis at 5–10 years follow-up showed no statistically significant difference in prognosis between MSI-positive and -negative tumours. Our results suggest that the MSI phenotype as such is not an independent prognostic factor. © 1999 Cancer Research Campaign
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spelling pubmed-23628572009-09-10 Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor Salahshor, S Kressner, U Fischer, H Lindmark, G Glimelius, B Påhlman, L Lindblom, A Br J Cancer Regular Article Hereditary non-polyposis colorectal cancer (HNPCC) is linked to an inherited defect in the DNA mismatch repair system. DNA from HNPCC tumours shows microsatellite instability (MSI). It has been reported that HNPCC patients have a better prognosis than patients with sporadic colorectal cancer. We examined whether the presence of MSI in a series of unselected colorectal tumours carries prognostic information. In a series of 181 unselected colorectal tumours, 22 tumours (12%) showed MSI. Survival analysis at 5–10 years follow-up showed no statistically significant difference in prognosis between MSI-positive and -negative tumours. Our results suggest that the MSI phenotype as such is not an independent prognostic factor. © 1999 Cancer Research Campaign Nature Publishing Group 1999-09 /pmc/articles/PMC2362857/ /pubmed/10496341 http://dx.doi.org/10.1038/sj.bjc.6690676 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Salahshor, S
Kressner, U
Fischer, H
Lindmark, G
Glimelius, B
Påhlman, L
Lindblom, A
Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
title Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
title_full Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
title_fullStr Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
title_full_unstemmed Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
title_short Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
title_sort microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362857/
https://www.ncbi.nlm.nih.gov/pubmed/10496341
http://dx.doi.org/10.1038/sj.bjc.6690676
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