Potent interaction of flavopiridol with MRP1

The multidrug resistance protein 1 (MRP1) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we show that flavopiridol, a synthetic flavonoid currently studied in phase 1 trials for its anti-proliferative characteristic...

Descripción completa

Detalles Bibliográficos
Autores principales: Hooijberg, J H, Broxterman, H J, Scheffer, G L, Vrasdonk, C, Heijn, M, Jong, M C de, Scheper, R J, Lankelma, J, Pinedo, HM
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362861/
https://www.ncbi.nlm.nih.gov/pubmed/10496352
http://dx.doi.org/10.1038/sj.bjc.6690687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362861/
https://www.ncbi.nlm.nih.gov/pubmed/10496352
http://dx.doi.org/10.1038/sj.bjc.6690687

Ejemplares similares