Cargando…

Potent interaction of flavopiridol with MRP1

The multidrug resistance protein 1 (MRP1) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we show that flavopiridol, a synthetic flavonoid currently studied in phase 1 trials for its anti-proliferative characteristic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hooijberg, J H, Broxterman, H J, Scheffer, G L, Vrasdonk, C, Heijn, M, Jong, M C de, Scheper, R J, Lankelma, J, Pinedo, HM
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362861/ https://www.ncbi.nlm.nih.gov/pubmed/10496352 http://dx.doi.org/10.1038/sj.bjc.6690687

Ejemplares similares

Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry.
por: Feller, N., et al.
Publicado: (1995)

Effect of P-glycoprotein on flavopiridol sensitivity
por: Boerner, S A, et al.
Publicado: (2001)

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
por: Evers, R, et al.
Publicado: (2000)

Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
por: Broxterman, H. J., et al.
Publicado: (1990)

Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen
por: Cimica, Velasco, et al.
Publicado: (2010)

Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
por: van Kalken, C. K., et al.
Publicado: (1993)

Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
por: Versantvoort, C. H., et al.
Publicado: (1993)

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport
por: Evers, R, et al.
Publicado: (2000)

Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP).
por: Hipfner, D. R., et al.
Publicado: (1998)

Flavopiridol Pharmacogenetics: Clinical and Functional Evidence for the Role of SLCO1B1/OATP1B1 in Flavopiridol Disposition
por: Ni, Wenjun, et al.
Publicado: (2010)

The Pharmacological Implications of Flavopiridol: An Updated Overview
por: Joshi, Hemant, et al.
Publicado: (2023)

The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance.
por: Schuurhuis, G. J., et al.
Publicado: (1990)

Highly sensitive and specific detection of P-glycoprotein function for haematological and solid tumour cells using a novel nucleic acid stain.
por: Broxterman, H. J., et al.
Publicado: (1997)

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein.
por: Schuurhuis, G. J., et al.
Publicado: (1991)

Transgenic models are predictive: the herceptin and flavopiridol experience
por: Schmidt, E
Publicado: (2003)

Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
por: Schuurhuis, G. J., et al.
Publicado: (1993)

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cells
por: Peaston, A E, et al.
Publicado: (2001)

Complex effects of flavopiridol on the expression of primary response genes
por: Keskin, Havva, et al.
Publicado: (2012)

Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells.
por: Eijdems, E. W., et al.
Publicado: (1995)

Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine
por: Adema, Auke D, et al.
Publicado: (2014)

Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation
por: Hu, Zi’ang, et al.
Publicado: (2018)

Application of an original RT-PCR–ELISA multiplex assay for MDR1 and MRP, along with p53 determination in node-positive breast cancer patients
por: Ferrero, J M, et al.
Publicado: (2000)

Interactions between subunits of Saccharomyces cerevisiae RNase MRP support a conserved eukaryotic RNase P/MRP architecture
por: Aspinall, Tanya V., et al.
Publicado: (2007)

The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer.
por: Nooter, K., et al.
Publicado: (1997)

A Phase II Study of Flavopiridol in Patients With Previously Untreated Advanced Soft Tissue Sarcoma
por: Morris, Don G., et al.
Publicado: (2006)

Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells
por: Li, Xiaoran, et al.
Publicado: (2017)

MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver
por: Belinsky, M G, et al.
Publicado: (1999)

The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells
por: Zocchi, Loredana, et al.
Publicado: (2018)

ABCC11/MRP8 Expression in the Gastrointestinal Tract and a Novel Role for Pepsinogen Secretion
por: Matsumoto, Hirofumi, et al.
Publicado: (2014)

Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells
por: van der Deen, Margaretha, et al.
Publicado: (2008)

Myeloid-related protein (MRP) 8 and MRP 14 in rheumatoid arthritis and spondyloarthropathy
por: De Rycke, L, et al.
Publicado: (2003)

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein.
por: Versantvoort, C. H., et al.
Publicado: (1995)

Serum MRP8/MRP14 as a biomarker for inflammation in autoimmune arthritis
por: De Rycke, L, et al.
Publicado: (2004)

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
por: Lam, Lloyd T, et al.
Publicado: (2001)

The radiation-sensitizing effect of flavopiridol in the esophageal cancer cell line Eca109
por: YAO, YUAN, et al.
Publicado: (2013)

The TLR4 ligands MRP8 and MRP14 in the diagnosis and pathogenesis of systemic onset juvenile idiopathic arthritis
por: Frosch, M, et al.
Publicado: (2008)

Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models
por: Pinto, Nicole, et al.
Publicado: (2020)

Risk Factors for Tumor Lysis Syndrome in patients with Chronic Lymphocytic Leukemia Treated with the Cyclin Dependent Kinase Inhibitor, Flavopiridol
por: Blum, Kristie A., et al.
Publicado: (2011)

The acridonecarboxamide GF120918 potently reverses P-glycoprotein-mediated resistance in human sarcoma MES-Dx5 cells
por: Traunecker, H C L, et al.
Publicado: (1999)

Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA
por: Hands-Taylor, Katherine L. D., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_d50i71odetabu3pvo0bfqg8p6r