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Dosimetric evaluation and radioimmunotherapy of anti-tumour multivalent Fab́ fragments

We have been investigating the use of cross-linked divalent (DFM) and trivalent (TFM) versions of the anti-carcinoembryonic antigen (CEA) monoclonal antibody A5B7 as possible alternatives to the parent forms (IgG and F(ab́)(2)) which have been used previously in clinical radioimmunotherapy (RIT) stu...

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Detalles Bibliográficos
Autores principales: Casey, J L, Pedley, R B, King, D J, Green, A J, Yarranton, G T, Begent, R H J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362943/
https://www.ncbi.nlm.nih.gov/pubmed/10576653
http://dx.doi.org/10.1038/sj.bjc.6690795