Targeted cytotoxic analogue of bombesin/ gastrin-releasing peptide inhibits the growth of H-69 human small-cell lung carcinoma in nude mice

Recently, we developed a powerful cytotoxic analogue of bombesin AN-215, in which the bombesin-like carrier peptide Gln–Trp–Ala–Val–Gly–His–Leu–Ψ(CH(2)-NH)–Leu–NH(2) (RC-3094) is conjugated to a potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201). Small-cell lung carcinomas (SCLCs) are...

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Detalles Bibliográficos
Autores principales: Kiaris, H, Schally, A V, Nagy, A, Sun, B, Armatis, P, Szepeshazi, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362957/
https://www.ncbi.nlm.nih.gov/pubmed/10576652
http://dx.doi.org/10.1038/sj.bjc.6690794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362957/
https://www.ncbi.nlm.nih.gov/pubmed/10576652
http://dx.doi.org/10.1038/sj.bjc.6690794

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