Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen

Angiostatin, a potent inhibitor of angiogenesis, tumour growth and metastasis, is a biologically active fragment of plasminogen, containing the kringle domains 1–4. It is generated from plasminogen by limited proteolysis. We show that prostate-specific antigen (PSA), a serine proteinase secreted by...

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Detalles Bibliográficos
Autores principales: Heidtmann, H-H, Nettelbeck, D M, Mingels, A, Jäger, R, Welker, H-G, Kontermann, R E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362961/
https://www.ncbi.nlm.nih.gov/pubmed/10604721
http://dx.doi.org/10.1038/sj.bjc.6692167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362961/
https://www.ncbi.nlm.nih.gov/pubmed/10604721
http://dx.doi.org/10.1038/sj.bjc.6692167

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