Schedule-dependent cytotoxicity of SN-38 in p53 wild-type and mutant colon adenocarcinoma cell lines

In this study the effects of SN-38 on colon adenocarcinoma cell lines expressing wild-type p53 (LS174T) or mutant non-functional p53 (HT29) have been investigated. On exposure to SN-38, HT29 cells rapidly progressed through G1 and S and arrested in G2/M. Release and concomitant increase in apoptosis...

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Detalles Bibliográficos
Autores principales: Poele, R H te, Joel, S P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362968/
https://www.ncbi.nlm.nih.gov/pubmed/10604724
http://dx.doi.org/10.1038/sj.bjc.6694370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362968/
https://www.ncbi.nlm.nih.gov/pubmed/10604724
http://dx.doi.org/10.1038/sj.bjc.6694370

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