Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice

Vesnarinone, an oral cardiotonic, inhibited the growth of several human non-small cell lung carcinoma cell lines, and its anti-proliferative effects in vitro and in vivo were greatly enhanced by combination with glucocorticoids, but not other steroids. Simultaneous treatment with vesnarinone and dex...

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Autores principales: Honma, Y, Yamamoto-Yamaguchi, Y, Kanatani, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363000/
https://www.ncbi.nlm.nih.gov/pubmed/10389984
http://dx.doi.org/10.1038/sj.bjc.6690327
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author Honma, Y
Yamamoto-Yamaguchi, Y
Kanatani, Y
author_facet Honma, Y
Yamamoto-Yamaguchi, Y
Kanatani, Y
author_sort Honma, Y
collection PubMed
description Vesnarinone, an oral cardiotonic, inhibited the growth of several human non-small cell lung carcinoma cell lines, and its anti-proliferative effects in vitro and in vivo were greatly enhanced by combination with glucocorticoids, but not other steroids. Simultaneous treatment with vesnarinone and dexamethasone is the most effective to evoke the synergistic effect in the growth inhibition of lung carcinoma EBC-1 cells. Dexamethasone and other glucocorticoids induced morphological changes in EBC-1 cells and these agents together with vesnarinone induced alkaline phosphatase activity, which is a typical marker of type II pneumocyte maturation. This treatment arrested the growth of the cells at the G(1) phase, indicating that this treatment is cytostatic rather than cytotoxic. These results suggest that vesnarinone plus glucocorticoid might be useful in lung cancer therapy. © 1999 Cancer Research Campaign
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spelling pubmed-23630002009-09-10 Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice Honma, Y Yamamoto-Yamaguchi, Y Kanatani, Y Br J Cancer Regular Article Vesnarinone, an oral cardiotonic, inhibited the growth of several human non-small cell lung carcinoma cell lines, and its anti-proliferative effects in vitro and in vivo were greatly enhanced by combination with glucocorticoids, but not other steroids. Simultaneous treatment with vesnarinone and dexamethasone is the most effective to evoke the synergistic effect in the growth inhibition of lung carcinoma EBC-1 cells. Dexamethasone and other glucocorticoids induced morphological changes in EBC-1 cells and these agents together with vesnarinone induced alkaline phosphatase activity, which is a typical marker of type II pneumocyte maturation. This treatment arrested the growth of the cells at the G(1) phase, indicating that this treatment is cytostatic rather than cytotoxic. These results suggest that vesnarinone plus glucocorticoid might be useful in lung cancer therapy. © 1999 Cancer Research Campaign Nature Publishing Group 1999-04 /pmc/articles/PMC2363000/ /pubmed/10389984 http://dx.doi.org/10.1038/sj.bjc.6690327 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Honma, Y
Yamamoto-Yamaguchi, Y
Kanatani, Y
Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
title Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
title_full Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
title_fullStr Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
title_full_unstemmed Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
title_short Vesnarinone and glucocorticoids cooperatively induce G(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
title_sort vesnarinone and glucocorticoids cooperatively induce g(1) arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363000/
https://www.ncbi.nlm.nih.gov/pubmed/10389984
http://dx.doi.org/10.1038/sj.bjc.6690327
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