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Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines

Apurinic/apyrimidinic (AP) sites in DNA are potentially lethal and mutagenic. They can arise spontaneously or following DNA damage from reactive oxygen species or alkylating agents, and they constitute a significant product of DNA damage following cellular exposure to ionizing radiation. The major A...

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Detalles Bibliográficos
Autores principales: Herring, C J, Deans, B, Elder, R H, Rafferty, J A, MacKinnon, J, Barzilay, G, Hickson, I D, Hendry, J H, Margison, GP
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363057/
https://www.ncbi.nlm.nih.gov/pubmed/10362100
http://dx.doi.org/10.1038/sj.bjc.6690447