Targeted disruption of the K-Ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis

The urokinase receptor, overexpressed in invasive colon cancer, promotes tumour cell invasion. Since K-Ras is activated in many colon cancers, we determined if urokinase receptor overexpression is a consequence of this activated oncogene. Accordingly, urokinase receptor expression was compared in HC...

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Detalles Bibliográficos
Autores principales: Allgayer, H, Wang, H, Shirasawa, S, Sasazuki, T, Boyd, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363146/
https://www.ncbi.nlm.nih.gov/pubmed/10471035
http://dx.doi.org/10.1038/sj.bjc.6690616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363146/
https://www.ncbi.nlm.nih.gov/pubmed/10471035
http://dx.doi.org/10.1038/sj.bjc.6690616

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