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Comparison of different methods of intracerebral administration of radioiododeoxyuridine for glioma therapy using a rat model

The Auger electron emitting agent 5-[(125)I]iodo-2′-deoxyuridine (i.e.[(125)I]IUdR) holds promise for the treatment of residual glioma after surgery because this thymidine analogue kills only proliferating cells. However, malignant cells which are not synthesizing DNA during exposure to the radiopha...

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Detalles Bibliográficos
Autores principales: Mairs, R J, Wideman, C L, Angerson, W J, Whateley, T L, Reza, M S, Reeves, J R, Robertson, L M, Neshasteh-Riz, A, Rampling, R, Owens, J, Allan, D, Graham, D I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363176/
https://www.ncbi.nlm.nih.gov/pubmed/10638969
http://dx.doi.org/10.1054/bjoc.1999.0879