Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Lage, H, Helmbach, H, Dietel, M, Schadendorf, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363299/
https://www.ncbi.nlm.nih.gov/pubmed/10646909
http://dx.doi.org/10.1054/bjoc.1999.0947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363299/
https://www.ncbi.nlm.nih.gov/pubmed/10646909
http://dx.doi.org/10.1054/bjoc.1999.0947

Ejemplares similares