Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activ...

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Autores principales: Lage, H, Helmbach, H, Dietel, M, Schadendorf, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363299/
https://www.ncbi.nlm.nih.gov/pubmed/10646909
http://dx.doi.org/10.1054/bjoc.1999.0947
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author Lage, H
Helmbach, H
Dietel, M
Schadendorf, D
author_facet Lage, H
Helmbach, H
Dietel, M
Schadendorf, D
author_sort Lage, H
collection PubMed
description The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of Topo II activity was reflected by decreased nuclear amounts of both Topo II isoforms. © 2000 Cancer Research Campaign
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spelling pubmed-23632992009-09-10 Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance Lage, H Helmbach, H Dietel, M Schadendorf, D Br J Cancer Regular Article The role of DNA topoisomerases (Topo) IIα and IIβ was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of Topo II activity was reflected by decreased nuclear amounts of both Topo II isoforms. © 2000 Cancer Research Campaign Nature Publishing Group 2000-01 2000-01-18 /pmc/articles/PMC2363299/ /pubmed/10646909 http://dx.doi.org/10.1054/bjoc.1999.0947 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Lage, H
Helmbach, H
Dietel, M
Schadendorf, D
Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
title Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
title_full Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
title_fullStr Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
title_full_unstemmed Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
title_short Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
title_sort modulation of dna topoisomerase ii activity and expression in melanoma cells with acquired drug resistance
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363299/
https://www.ncbi.nlm.nih.gov/pubmed/10646909
http://dx.doi.org/10.1054/bjoc.1999.0947
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AT dietelm modulationofdnatopoisomeraseiiactivityandexpressioninmelanomacellswithacquireddrugresistance
AT schadendorfd modulationofdnatopoisomeraseiiactivityandexpressioninmelanomacellswithacquireddrugresistance

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