Hypermethylation of ribosomal DNA in human breast carcinoma

We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P< 0.0001). This increased rDNA methylation was associated with o...

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Autores principales: Yan, P S, Rodriguez, F J, Laux, D E, Perry, M R, Standiford, S B, Huang, T H-M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363317/
https://www.ncbi.nlm.nih.gov/pubmed/10682657
http://dx.doi.org/10.1054/bjoc.1999.0955
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author Yan, P S
Rodriguez, F J
Laux, D E
Perry, M R
Standiford, S B
Huang, T H-M
author_facet Yan, P S
Rodriguez, F J
Laux, D E
Perry, M R
Standiford, S B
Huang, T H-M
author_sort Yan, P S
collection PubMed
description We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P< 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P< 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P< 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. © 2000 Cancer Research Campaign
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spelling pubmed-23633172009-09-10 Hypermethylation of ribosomal DNA in human breast carcinoma Yan, P S Rodriguez, F J Laux, D E Perry, M R Standiford, S B Huang, T H-M Br J Cancer Regular Article We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P< 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P< 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P< 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. © 2000 Cancer Research Campaign Nature Publishing Group 2000-02 2000-01-18 /pmc/articles/PMC2363317/ /pubmed/10682657 http://dx.doi.org/10.1054/bjoc.1999.0955 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Yan, P S
Rodriguez, F J
Laux, D E
Perry, M R
Standiford, S B
Huang, T H-M
Hypermethylation of ribosomal DNA in human breast carcinoma
title Hypermethylation of ribosomal DNA in human breast carcinoma
title_full Hypermethylation of ribosomal DNA in human breast carcinoma
title_fullStr Hypermethylation of ribosomal DNA in human breast carcinoma
title_full_unstemmed Hypermethylation of ribosomal DNA in human breast carcinoma
title_short Hypermethylation of ribosomal DNA in human breast carcinoma
title_sort hypermethylation of ribosomal dna in human breast carcinoma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363317/
https://www.ncbi.nlm.nih.gov/pubmed/10682657
http://dx.doi.org/10.1054/bjoc.1999.0955
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