NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line

Tirapazamine (TPZ, SR4233, WIN 59075) is a bioreductive drug that is activated in regions of low oxygen tension to a cytotoxic radical intermediate. This labile metabolite shows high selective toxicity towards hypoxic cells, such as those found in solid tumours. Under aerobic conditions, redox cycli...

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Detalles Bibliográficos
Autores principales: Saunders, M P, Patterson, A V, Chinje, E C, Harris, A L, Stratford, I J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363339/
https://www.ncbi.nlm.nih.gov/pubmed/10682679
http://dx.doi.org/10.1054/bjoc.1999.0977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363339/
https://www.ncbi.nlm.nih.gov/pubmed/10682679
http://dx.doi.org/10.1054/bjoc.1999.0977

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