Mutational status of K- ras and TP53 genes in primary sarcomas of the heart

We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K- ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K- ras, three patients...

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Autores principales: Garcia, J M, Gonzalez, R, Silva, J M, Dominguez, G, Vegazo, I S, Gamallo, C, Provencio, M, España, P, Bonilla, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363343/
https://www.ncbi.nlm.nih.gov/pubmed/10735503
http://dx.doi.org/10.1054/bjoc.1999.1060
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author Garcia, J M
Gonzalez, R
Silva, J M
Dominguez, G
Vegazo, I S
Gamallo, C
Provencio, M
España, P
Bonilla, F
author_facet Garcia, J M
Gonzalez, R
Silva, J M
Dominguez, G
Vegazo, I S
Gamallo, C
Provencio, M
España, P
Bonilla, F
author_sort Garcia, J M
collection PubMed
description We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K- ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K- ras, three patients (60%) presented the same mutation at the first base of codon 13 (G to A transition). Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types. © 2000 Cancer Research Campaign
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spelling pubmed-23633432009-09-10 Mutational status of K- ras and TP53 genes in primary sarcomas of the heart Garcia, J M Gonzalez, R Silva, J M Dominguez, G Vegazo, I S Gamallo, C Provencio, M España, P Bonilla, F Br J Cancer Regular Article We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K- ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K- ras, three patients (60%) presented the same mutation at the first base of codon 13 (G to A transition). Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types. © 2000 Cancer Research Campaign Nature Publishing Group 2000-03 2000-02-21 /pmc/articles/PMC2363343/ /pubmed/10735503 http://dx.doi.org/10.1054/bjoc.1999.1060 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Garcia, J M
Gonzalez, R
Silva, J M
Dominguez, G
Vegazo, I S
Gamallo, C
Provencio, M
España, P
Bonilla, F
Mutational status of K- ras and TP53 genes in primary sarcomas of the heart
title Mutational status of K- ras and TP53 genes in primary sarcomas of the heart
title_full Mutational status of K- ras and TP53 genes in primary sarcomas of the heart
title_fullStr Mutational status of K- ras and TP53 genes in primary sarcomas of the heart
title_full_unstemmed Mutational status of K- ras and TP53 genes in primary sarcomas of the heart
title_short Mutational status of K- ras and TP53 genes in primary sarcomas of the heart
title_sort mutational status of k- ras and tp53 genes in primary sarcomas of the heart
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363343/
https://www.ncbi.nlm.nih.gov/pubmed/10735503
http://dx.doi.org/10.1054/bjoc.1999.1060
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