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Prolonged and enhanced suppression of thymidylate synthase by weekly 24-h infusion of high-dose 5-fluorouracil

We have recently demonstrated that HDFL (high-dose 5-FU 2600 mg m–2 week–1 and leucovorin 500 mg m–2 week–1, weekly 24-h infusion) is highly active in the treatment of gastric cancer. To further clarify the possible mechanism underlying the improved activity of HDFL compared with conventional 5-FU r...

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Detalles Bibliográficos
Autores principales:	Yeh, K-H, Yeh, S-H, Hsu, C-H, Wang, T-M, Ma, I-F, Cheng, A-L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363429/ https://www.ncbi.nlm.nih.gov/pubmed/11076661 http://dx.doi.org/10.1054/bjoc.2000.1456

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