Cargando…

Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases

Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palmieri, G, Cossu, A, Ascierto, P A, Botti, G, Strazzullo, M, Lissia, A, Colombino, M, Casula, M, Floris, C, Tanda, F, Pirastu, M, Castello, G
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363459/ https://www.ncbi.nlm.nih.gov/pubmed/11104570 http://dx.doi.org/10.1054/bjoc.2000.1513

Ejemplares similares

Genetic alterations in main candidate genes during melanoma progression
por: Sini, Maria Cristina, et al.
Publicado: (2018)

Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach
por: Manca, Antonella, et al.
Publicado: (2019)

Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas
por: Manca, Antonella, et al.
Publicado: (2015)

Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
por: Palmieri, Giuseppe, et al.
Publicado: (2017)

Issues affecting molecular staging in the management of patients with melanoma
por: Palmieri, G, et al.
Publicado: (2007)

Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma
por: Colombino, Maria, et al.
Publicado: (2013)

Comparison of BRAF Mutation Screening Strategies in a Large Real-Life Series of Advanced Melanoma Patients
por: Colombino, Maria, et al.
Publicado: (2020)

Assessment of germline and somatic alterations in main candidate genes among patients with multiple primary melanoma
por: Colombino, Maria, et al.
Publicado: (2014)

BRAF Mutations and Dysregulation of the MAP Kinase Pathway Associated to Sinonasal Mucosal Melanomas
por: Colombino, Maria, et al.
Publicado: (2019)

Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study
por: Casula, Milena, et al.
Publicado: (2019)

Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets
por: Palmieri, Giuseppe, et al.
Publicado: (2015)

Molecular Pathways in Melanomagenesis: What We Learned from Next-Generation Sequencing Approaches
por: Palmieri, Giuseppe, et al.
Publicado: (2018)

Discrepant alterations in main candidate genes among multiple primary melanomas
por: Colombino, Maria, et al.
Publicado: (2014)

Primary Dermal Melanoma in a Patient with a History of Multiple Malignancies: A Case Report with Molecular Characterization
por: Sini, Germana, et al.
Publicado: (2013)

Primary Melanoma of the Lung: A Systematic Review
por: Paliogiannis, Panagiotis, et al.
Publicado: (2020)

Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective
por: Ombra, Maria Neve, et al.
Publicado: (2019)

Quality assessment of a clinical next-generation sequencing melanoma panel within the Italian Melanoma Intergroup (IMI)
por: Vanni, Irene, et al.
Publicado: (2020)

Deletion analysis of chromosome 8p in sporadic colorectal adenomas.
por: Cunningham, C., et al.
Publicado: (1994)

Serial detection of circulating tumour cells by reverse transcriptase-polymerase chain reaction assays is a marker for poor outcome in patients with malignant melanoma
por: Palmieri, Giuseppe, et al.
Publicado: (2006)

Vitamin D status and risk for malignant cutaneous melanoma: recent advances
por: Ombra, Maria N., et al.
Publicado: (2017)

Identification of a founder BRCA2 mutation in Sardinia
por: Pisano, M, et al.
Publicado: (2000)

Recurrent Chromosomal Copy Number Alterations in Sporadic Chordomas
por: Le, Long Phi, et al.
Publicado: (2011)

The clinical phenotype of hereditary versus sporadic prostate cancer: HPC definition revisited
por: Cremers, Ruben G., et al.
Publicado: (2016)

Perivascular Epithelioid Cell Tumors (PEComas) of the Orbit
por: Paliogiannis, Panagiotis, et al.
Publicado: (2017)

BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy
por: Colombino, M, et al.
Publicado: (2012)

Are Molecular Alterations Linked to Genetic Instability Worth to Be Included as Biomarkers for Directing or Excluding Melanoma Patients to Immunotherapy?
por: Palmieri, Giuseppe, et al.
Publicado: (2021)

Comparison between Three Different Techniques for the Detection of EGFR Mutations in Liquid Biopsies of Patients with Advanced Stage Lung Adenocarcinoma
por: Casula, Milena, et al.
Publicado: (2023)

Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.
por: Grundy, R. G., et al.
Publicado: (1998)

KIT and PDGFRa mutational patterns in Sardinian patients with gastrointestinal stromal tumors
por: Palomba, Grazia, et al.
Publicado: (2020)

EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma
por: Colombino, Maria, et al.
Publicado: (2019)

KRAS mutational concordance between primary and metastatic colorectal adenocarcinoma
por: PALIOGIANNIS, PANAGIOTIS, et al.
Publicado: (2014)

Frequent Loss of Heterozygosity at the MCC Locus on Chromosome 5q21‐22 in Sporadic Colorectal Carcinomas
por: Miki, Yoshio, et al.
Publicado: (1991)

Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report
por: Pulighe, Fabio, et al.
Publicado: (2013)

Chromosome 5 allele loss in familial and sporadic colorectal adenomas.
por: Rees, M., et al.
Publicado: (1989)

Early surgery and definitive cure in small sporadic vestibular schwannoma
por: Zanoletti, Elisabetta, et al.
Publicado: (2022)

Global prognostic impact of driver genetic alterations in patients with lung adenocarcinoma: a real-life study
por: Paliogiannis, Panagiotis, et al.
Publicado: (2022)

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
por: Shatunov, Aleksey, et al.
Publicado: (2010)

Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia
por: Palomba, Grazia, et al.
Publicado: (2012)

Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy
por: Casula, Milena, et al.
Publicado: (2009)

Long Survival in a Patient with Brain Metastases from Breast Cancer
por: G, Sanna, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_neoj8ija067q8639l97mf2lvfc