A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours

Because tumour cell proliferation is highly dependent upon up-regulation of de-novo polyamine synthesis, inhibition of the polyamine synthesis pathway represents a potential target for anticancer therapy. SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionin...

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Detalles Bibliográficos
Autores principales: Paridaens, R, Uges, D R A, Barbet, N, Choi, L, Seeghers, M, Graaf, W T A van der, Groen, H J M, Dumez, H, Buuren, I Van, Muskiet, F, Capdeville, R, Oosterom, A T van, Vries, E G E de
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363502/
https://www.ncbi.nlm.nih.gov/pubmed/10944598
http://dx.doi.org/10.1054/bjoc.2000.1305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363502/
https://www.ncbi.nlm.nih.gov/pubmed/10944598
http://dx.doi.org/10.1054/bjoc.2000.1305

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