Cargando…

A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours

Because tumour cell proliferation is highly dependent upon up-regulation of de-novo polyamine synthesis, inhibition of the polyamine synthesis pathway represents a potential target for anticancer therapy. SAM486A (CGP 48664) is a new inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paridaens, R, Uges, D R A, Barbet, N, Choi, L, Seeghers, M, Graaf, W T A van der, Groen, H J M, Dumez, H, Buuren, I Van, Muskiet, F, Capdeville, R, Oosterom, A T van, Vries, E G E de
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363502/ https://www.ncbi.nlm.nih.gov/pubmed/10944598 http://dx.doi.org/10.1054/bjoc.2000.1305

Ejemplares similares

A prolonged methoxymorpholino doxorubicin (PNU-152243 or MMRDX) infusion schedule in patients with solid tumours: a phase 1 and pharmacokinetic study
por: Fokkema, E, et al.
Publicado: (2000)

A phase I study with MAG-camptothecin intravenously administered weekly for 3 weeks in a 4-week cycle in adult patients with solid tumours
por: Wachters, F M, et al.
Publicado: (2004)

Continuous carboplatin infusion during 6 weeks' radiotherapy in locally inoperable non-small-cell lung cancer: a phase I and pharmacokinetic study.
por: Groen, H. J., et al.
Publicado: (1995)

Randomized comparison of etoposide pharmacokinetics after oral etoposide phosphate and oral etoposide.
por: de Jong, R. S., et al.
Publicado: (1997)

Kinetic and structural characterization of carboxyspermidine dehydrogenase of polyamine biosynthesis
por: Lee, Danielle F., et al.
Publicado: (2023)

Targeting polyamine biosynthesis to stimulate beta cell regeneration in zebrafish
por: Robertson, Morgan A., et al.
Publicado: (2020)

Polyamine biosynthesis is critical for growth and differentiation of the pancreas
por: Mastracci, Teresa L., et al.
Publicado: (2015)

CsCDPK6, a CsSAMS1-Interacting Protein, Affects Polyamine/Ethylene Biosynthesis in Cucumber and Enhances Salt Tolerance by Overexpression in Tobacco
por: Zhu, Heyuan, et al.
Publicado: (2021)

Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene
por: Maring, J G, et al.
Publicado: (2002)

Carbon extension in peptidylnucleoside biosynthesis by radical-SAM enzymes
por: Lilla, Edward A., et al.
Publicado: (2016)

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin
por: Jong, R S de, et al.
Publicado: (1999)

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy
por: Holbert, Cassandra E., et al.
Publicado: (2022)

Citrus Polyamines: Structure, Biosynthesis, and Physiological Functions
por: Killiny, Nabil, et al.
Publicado: (2020)

Structure and biosynthesis of deoxy-polyamine in Xenorhabdus bovienii
por: Wenski, Sebastian L, et al.
Publicado: (2021)

Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
por: Withoff, S., et al.
Publicado: (1996)

Understanding the Effects of Trenbolone Acetate, Polyamine Precursors, and Polyamines on Proliferation, Protein Synthesis Rates, and the Abundance of Genes Involved in Myoblast Growth, Polyamine Biosynthesis, and Protein Synthesis in Murine Myoblasts
por: Motsinger, Laura A., et al.
Publicado: (2023)

Arginine Catabolism and Polyamine Biosynthesis Pathway Disparities Within Francisella tularensis Subpopulations
por: Yue, Yinshi, et al.
Publicado: (2022)

Radical SAM-dependent ether crosslink in daropeptide biosynthesis
por: Guo, Sijia, et al.
Publicado: (2022)

Radical SAM Enzymes Involved in Tetrapyrrole Biosynthesis and Insertion
por: Layer, Gunhild, et al.
Publicado: (2022)

Control of the polyamine biosynthesis pathway by G(2)-quadruplexes
por: Lightfoot, Helen Louise, et al.
Publicado: (2018)

Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes
por: Sims, Emily K., et al.
Publicado: (2023)

Regulated Expression of an Essential Allosteric Activator of Polyamine Biosynthesis in African Trypanosomes
por: Willert, Erin K., et al.
Publicado: (2008)

The Biosynthesis and Functions of Polyamines in the Interaction of Plant Growth-Promoting Rhizobacteria with Plants
por: Dunn, Michael F., et al.
Publicado: (2023)

MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions
por: ElKhouly, Aisha M., et al.
Publicado: (2020)

Overall Retention of Methyl Stereochemistry during B(12)-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis
por: McLaughlin, Martin I., et al.
Publicado: (2021)

Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692
por: Ayikpoe, Richard S., et al.
Publicado: (2023)

Impact of nicotine pathway downregulation on polyamine biosynthesis and leaf ripening in tobacco
por: Nölke, Greta, et al.
Publicado: (2021)

Concomitant oral tyrosine kinase inhibitors and bisphosphonates in advanced renal cell carcinoma with bone metastases
por: Beuselinck, B, et al.
Publicado: (2012)

Alkaline Stress Causes Changes in Polyamine Biosynthesis in Thermus thermophilus
por: Kobayashi, Teruyuki, et al.
Publicado: (2022)

Phase II and pharmacokinetic study of lobaplatin in patients with relapsed ovarian cancer.
por: Gietema, J. A., et al.
Publicado: (1995)

The Mechanism of Dedoping PEDOT:PSS by Aliphatic Polyamines
por: van der Pol, Tom P. A., et al.
Publicado: (2019)

Broad phase II and pharmacokinetic study of methoxy-morpholino doxorubicin (FCE 23762-MMRDX) in non-small-cell lung cancer, renal cancer and other solid tumour patients.
por: Bakker, M., et al.
Publicado: (1998)

Polyamine Action under Metal/Metalloid Stress: Regulation of Biosynthesis, Metabolism, and Molecular Interactions
por: Hasanuzzaman, Mirza, et al.
Publicado: (2019)

A RubisCO like protein links SAM metabolism with isoprenoid biosynthesis
por: Erb, Tobias J., et al.
Publicado: (2012)

Practical Synthesis of Polyamine Succinamides and Branched Polyamines
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2022)

SAM-Dependent Enzyme-Catalysed Pericyclic Reactions in Natural Product Biosynthesis
por: Ohashi, Masao, et al.
Publicado: (2017)

Doxorubicin vs epirubicin, report of a second-line randomized phase II/III study in advanced breast cancer. EORTC Breast Cancer Cooperative Group.
por: Bontenbal, M., et al.
Publicado: (1998)

Aminopropyltransferases Involved in Polyamine Biosynthesis Localize Preferentially in the Nucleus of Plant Cells
por: Belda-Palazón, Borja, et al.
Publicado: (2012)

Conversion of the prodrug etoposide phosphate to etoposide in gastric juice and bile.
por: de Jong, R. S., et al.
Publicado: (1997)

Deployment of SAM for the CDF Experiment
por: Stonjek, S, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_u9ergbu02tqe6fifq57sr5ngl5